Glaser et al. tested measures of government perform, IQ, and memory in 34 kids and younger adults with the 22q11.2 microdeletion . No vital differences were detected between met- and val-hemizygous individuals on measures of executive perform. https://enzymes.bio/ didn't differ on full-scale, performance, and verbal IQ or on verbal and visual memory.
COMT is ubiquitously expressed, with the highest COMT exercise occurring in the liver and kidneys. Notable expression of COMT occurs in kidney proximal tubular epithelial cells, where the enzyme is believed to not directly regulate the metabolism of dopamine and other catecholamines. However, a major focus of analysis has been the involvement of COMT within the opposed results associated with the use of levodopa for Parkinson's disease remedy. Patients with DiGeorge syndrome are hemizygous for the COMT gene.
Glaser et al. advised that either the COMT polymorphism has a small impact on executive perform in 22q11.2 deletion syndrome or no impact exists in any respect. Suicidal behavior is usually correlated with other-directed aggression, which is believed to be partially mediated by catecholaminergic neurotransmission.
Rujescu et al. examined the affect of the V158M polymorphism on suicidal behavior and anger-related traits. By Taq polymerase digestion of PCR products, they genotyped 149 German suicide attempters and 328 German control topics. There was no total distinction in allele/genotype frequency between patients and management topics. However, the low exercise L allele was overrepresented in violent suicide attempters (sixty two% vs fifty one%). LL carriers expressed their anger more outwardly versus HH carriers who expressed it more inwardly, and they reported more state anger, as assessed by the State-Trait Anger Expression Inventory.
Rujescu et al. interpreted these findings as supporting the speculation that this functional polymorphism could modify the phenotype of suicide makes an attempt and anger-related traits. Woo et al. studied fifty one sufferers meeting DSM-IV standards for panic dysfunction and 45 healthy comparison subjects for the V158M polymorphism. The frequency of the met/met genotype was significantly higher in sufferers with panic disorder than in wholesome subjects (19.6% vs 2.2%).
